Unknown; not sympathomimetic; may possibly raise dopamine amounts within the brain by binding on the dopamine transporter and inhibiting dopamine reuptake
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Moreover, the purportedly “reduced” abuse probable of modafinil only applies to scenarios where it is remaining taken by prescription and with oversight from the accredited health-related Skilled.
In the same way, it really is presently unknown no matter whether modafinil may be transmitted to an infant by way of breastmilk, and related cautions use to modafinil use by moms who're nursing [38].
EMA ble opprettet i 1995 for å sikre best mulig utnyttelse av Europas vitenskapelige ressurser for evaluering av, tilsyn med og overvåkning av legemidler.
Keep track of INR much more commonly if coadministered with inhibitors of these isoenzymes and adjust warfarin dose if essential.
Obstructive slumber apnea is often a dysfunction whose key symptom would be the cessation of respiratory mainly because of the blockage in the higher respiratory airways in the course of sleeping.
Doses as many as 400 mg/day, given as an individual dose, are effectively tolerated, but there's no regular proof this dose confers extra advantage outside of that of the two hundred mg/working day dose
Dose adjustments of those prescription drugs together with other medicine which have been substrates for CYP2C19 may very well be essential if modafinil is coadministered
Based on an observational examine of eleven people today on opioid medicines, modafinil reportedly reduced sleepiness with no disrupting the individuals’ snooze designs.
fosphenytoin will lessen the level or outcome of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
It is not acknowledged irrespective of whether this medicine will damage an unborn newborn. Convey to your health practitioner Should more info you be pregnant or strategy to be pregnant.
The existing review employed meta-analysis to combine the readily available literature about the remedy of modafinil on exhaustion and EDS associated with neurological disorders and assessed the efficacy of modafinil on tiredness and EDS and its basic safety in clients with neurological diseases that has a rigorous methodological high-quality evaluation.
Modafinil is researched to find out no matter if it would boost abstinence in people with copyright addiction.[258]